Two types of human Th17 cells with pro- and anti-inflammatory properties and distinct roles in autoinflammation

Introduction Th17 cells are known to be crucial mediators of autoimmune inflammation. However, two distinct types of Th17 cells have recently been described, which differed in their ability to coproduce IL-10 or IFN-g due to differential polarizations requirements for IL-1b. Whether these distinct Th17 phenotypes translate into distinct Th17 cell functions and whether this has implications for human health or disease has not been addressed yet.